Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding

The importance of allosteric proteasome inhibition in the treatment of cancer is becoming increasingly evident. Motivated by this urgent therapeutic need, we have recently identified cationic porphyrins as a highly versatile class of molecules able to regulate proteasome activity by interfering with...

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Detalles Bibliográficos
Autores principales: Dato, Antonio Di, Cunsolo, Alessandra, Persico, Marco, Santoro, Anna Maria, D’Urso, Alessandro, Milardi, Danilo, Purrello, Roberto, Stefanelli, Manuela, Paolesse, Roberto, Tundo, Grazia R., Sbardella, Diego, Fattorusso, Caterina, Coletta, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719074/
https://www.ncbi.nlm.nih.gov/pubmed/29213119
http://dx.doi.org/10.1038/s41598-017-17008-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719074/
https://www.ncbi.nlm.nih.gov/pubmed/29213119
http://dx.doi.org/10.1038/s41598-017-17008-7

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