Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells

Indoxyl sulfate (IS) induces fibrosis and inflammation in kidneys via oxidative stress through the induction of transforming growth factor-β1 (TGF-β1) and monocyte chemotactic protein-1 (MCP-1). Furthermore, IS is a potent endogenous agonist for aryl hydrocarbon receptor (AHR), which regulates the t...

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Detalles Bibliográficos
Autores principales: Yisireyili, Maimaiti, Takeshita, Kyosuke, Saito, Shinichi, Murohara, Toyoaki, Niwa, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719207/
https://www.ncbi.nlm.nih.gov/pubmed/29238104
http://dx.doi.org/10.18999/nagjms.79.4.477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719207/
https://www.ncbi.nlm.nih.gov/pubmed/29238104
http://dx.doi.org/10.18999/nagjms.79.4.477

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