RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus

During the development of autoimmune disease, a switch occurs in the antibody repertoire of B cells so that the production of pathogenic rather than non-pathogenic autoantibodies is enabled. However, there is limited knowledge concerning how this pivotal step occurs. Here, we present genetic and pha...

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Detalles Bibliográficos
Autores principales: Mandik-Nayak, Laura, DuHadaway, James B., Mulgrew, Jennifer, Pigott, Elizabeth, Manley, Kaylend, Sedano, Summer, Prendergast, George C., Laury-Kleintop, Lisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719251/
https://www.ncbi.nlm.nih.gov/pubmed/28882929
http://dx.doi.org/10.1242/dmm.029835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719251/
https://www.ncbi.nlm.nih.gov/pubmed/28882929
http://dx.doi.org/10.1242/dmm.029835

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