Toll-like Receptor Activation Induces Degeneration of Human Intervertebral Discs

Toll-like receptors (TLR) are activated by endogenous alarmins such as fragmented extracellular matrix compounds found in the degenerating disc. TLRs regulate cytokine, neurotrophin, and protease expression in human disc cells in vitro, and thus control key factors in disc degeneration. However, whe...

Descripción completa

Detalles Bibliográficos
Autores principales: Krock, Emerson, Rosenzweig, Derek H., Currie, J. Brooke, Bisson, Daniel G., Ouellet, Jean A., Haglund, Lisbet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719358/
https://www.ncbi.nlm.nih.gov/pubmed/29215065
http://dx.doi.org/10.1038/s41598-017-17472-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719358/
https://www.ncbi.nlm.nih.gov/pubmed/29215065
http://dx.doi.org/10.1038/s41598-017-17472-1

Ejemplares similares