β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing

Familial mutations in C99 can increase the total level of the soluble Aβ peptides produced by proteolysis, as well as the Aβ42/Aβ40 ratio, both of which are linked to the progression of Alzheimer’s disease. We show that the extracellular sequence of C99 forms β-sheet structure upon interaction with...

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Detalles Bibliográficos
Autores principales: Hu, Yi, Kienlen-Campard, Pascal, Tang, Tzu-Chun, Perrin, Florian, Opsomer, Rémi, Decock, Marie, Pan, Xiaoshu, Octave, Jean-Noel, Constantinescu, Stefan N., Smith, Steven O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719365/
https://www.ncbi.nlm.nih.gov/pubmed/29215043
http://dx.doi.org/10.1038/s41598-017-17144-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719365/
https://www.ncbi.nlm.nih.gov/pubmed/29215043
http://dx.doi.org/10.1038/s41598-017-17144-0

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