Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report...

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Detalles Bibliográficos
Autores principales: Zhong, Wenhe, Cui, Liang, Goh, Boon Chong, Cai, Qixu, Ho, Peiying, Chionh, Yok Hian, Yuan, Meng, Sahili, Abbas El, Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Lescar, Julien, Dedon, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719368/
https://www.ncbi.nlm.nih.gov/pubmed/29215013
http://dx.doi.org/10.1038/s41467-017-02086-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719368/
https://www.ncbi.nlm.nih.gov/pubmed/29215013
http://dx.doi.org/10.1038/s41467-017-02086-y

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