NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A

The adaptor protein TRAF6 has a central function in Toll-like receptor (TLR) signalling, yet the molecular mechanisms controlling its activity and stability are unclear. Here we show that NLRP11, a primate specific gene, inhibits TLR signalling by targeting TRAF6 for degradation. NLRP11 recruits the...

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Detalles Bibliográficos
Autores principales: Wu, Chenglei, Su, Zexiong, Lin, Meng, Ou, Jiayu, Zhao, Wei, Cui, Jun, Wang, Rong-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719394/
https://www.ncbi.nlm.nih.gov/pubmed/29215004
http://dx.doi.org/10.1038/s41467-017-02073-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719394/
https://www.ncbi.nlm.nih.gov/pubmed/29215004
http://dx.doi.org/10.1038/s41467-017-02073-3

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