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Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease
Influenza is a serious hazard to human health that causes hundreds of thousands of deaths annually. Though vaccines and current therapeutics can blunt some of the perilous impact of this viral infection, new treatments are needed due to the constantly evolving nature of this virus. Recently, our gro...
Autores principales: | Beylkin, Diane, Kumar, Gyanendra, Zhou, Wei, Park, Jaehyeon, Jeevan, Trushar, Lagisetti, Chandraiah, Harfoot, Rhodri, Webby, Richard J., White, Stephen W., Webb, Thomas R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719402/ https://www.ncbi.nlm.nih.gov/pubmed/29215062 http://dx.doi.org/10.1038/s41598-017-17419-6 |
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