Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal. DMD patients lack the expression of the structural protein dystrophin caused by mutations within the DMD gene. The absence of functional dystrophin protein results in excessive damage from normal muscle use due to t...

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Detalles Bibliográficos
Autores principales: Welch, Ryan D., Billon, Cyrielle, Valfort, Aurore-Cecile, Burris, Thomas P., Flaveny, Colin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719458/
https://www.ncbi.nlm.nih.gov/pubmed/29215066
http://dx.doi.org/10.1038/s41598-017-17496-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719458/
https://www.ncbi.nlm.nih.gov/pubmed/29215066
http://dx.doi.org/10.1038/s41598-017-17496-7

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