Enzyme Architecture: Erection of Active Orotidine 5′-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes

[Image: see text] Orotidine 5′-monophosphate decarboxylase (OMPDC) catalyzes the decarboxylation of 5-fluoroorotate (FO) with k(cat)/K(m) = 1.4 × 10(–7) M(–1) s(–1). Combining this and related kinetic parameters shows that the 31 kcal/mol stabilization of the transition state for decarboxylation of...

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Detalles Bibliográficos
Autores principales: Reyes, Archie C., Amyes, Tina L., Richard, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720041/
https://www.ncbi.nlm.nih.gov/pubmed/29058891
http://dx.doi.org/10.1021/jacs.7b08897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720041/
https://www.ncbi.nlm.nih.gov/pubmed/29058891
http://dx.doi.org/10.1021/jacs.7b08897

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