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Enzyme Architecture: Erection of Active Orotidine 5′-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes
[Image: see text] Orotidine 5′-monophosphate decarboxylase (OMPDC) catalyzes the decarboxylation of 5-fluoroorotate (FO) with k(cat)/K(m) = 1.4 × 10(–7) M(–1) s(–1). Combining this and related kinetic parameters shows that the 31 kcal/mol stabilization of the transition state for decarboxylation of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720041/ https://www.ncbi.nlm.nih.gov/pubmed/29058891 http://dx.doi.org/10.1021/jacs.7b08897 |