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Two distinct nodes of translational inhibition in the Integrated Stress Response

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped...

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Detalles Bibliográficos
Autores principales: Ryoo, Hyung Don, Vasudevan, Deepika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720466/
https://www.ncbi.nlm.nih.gov/pubmed/28803610
http://dx.doi.org/10.5483/BMBRep.2017.50.11.157