Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human l...

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Detalles Bibliográficos
Autores principales: McGranahan, Nicholas, Rosenthal, Rachel, Hiley, Crispin T., Rowan, Andrew J., Watkins, Thomas B.K., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Van Loo, Peter, Herrero, Javier, Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720478/
https://www.ncbi.nlm.nih.gov/pubmed/29107330
http://dx.doi.org/10.1016/j.cell.2017.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720478/
https://www.ncbi.nlm.nih.gov/pubmed/29107330
http://dx.doi.org/10.1016/j.cell.2017.10.001

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