Determination of Etelcalcetide Biotransformation and Hemodialysis Kinetics to Guide the Timing of Its Dosing

INTRODUCTION: Etelcalcetide, a novel calcimimetic agonist of the calcium-sensing receptor for treatment of secondary hyperparathyroidism in chronic kidney disease patients on hemodialysis, is a d-amino acid linear heptapeptide with a d-cysteine that is linked to an l-cysteine by a disulfide bond. In...

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Detalles Bibliográficos
Autores principales: Edson, Katheryne Z., Wu, Benjamin M., Iyer, Abhinaya, Goodman, William, Skiles, Gary L., Subramanian, Raju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720529/
https://www.ncbi.nlm.nih.gov/pubmed/29318205
http://dx.doi.org/10.1016/j.ekir.2016.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720529/
https://www.ncbi.nlm.nih.gov/pubmed/29318205
http://dx.doi.org/10.1016/j.ekir.2016.04.002

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