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Determination of Etelcalcetide Biotransformation and Hemodialysis Kinetics to Guide the Timing of Its Dosing

INTRODUCTION: Etelcalcetide, a novel calcimimetic agonist of the calcium-sensing receptor for treatment of secondary hyperparathyroidism in chronic kidney disease patients on hemodialysis, is a d-amino acid linear heptapeptide with a d-cysteine that is linked to an l-cysteine by a disulfide bond. In...

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Detalles Bibliográficos
Autores principales:	Edson, Katheryne Z., Wu, Benjamin M., Iyer, Abhinaya, Goodman, William, Skiles, Gary L., Subramanian, Raju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720529/ https://www.ncbi.nlm.nih.gov/pubmed/29318205 http://dx.doi.org/10.1016/j.ekir.2016.04.002

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