Nodal patterning without Lefty inhibitory feedback is functional but fragile

Developmental signaling pathways often activate their own inhibitors. Such inhibitory feedback has been suggested to restrict the spatial and temporal extent of signaling or mitigate signaling fluctuations, but these models are difficult to rigorously test. Here, we determine whether the ability of...

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Detalles Bibliográficos
Autores principales: Rogers, Katherine W, Lord, Nathan D, Gagnon, James A, Pauli, Andrea, Zimmerman, Steven, Aksel, Deniz C, Reyon, Deepak, Tsai, Shengdar Q, Joung, J Keith, Schier, Alexander F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720593/
https://www.ncbi.nlm.nih.gov/pubmed/29215332
http://dx.doi.org/10.7554/eLife.28785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720593/
https://www.ncbi.nlm.nih.gov/pubmed/29215332
http://dx.doi.org/10.7554/eLife.28785

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