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Global computational mutagenesis provides a critical stability framework in protein structures
A protein’s amino acid sequence dictates the folds and final structure the macromolecule will form. We propose that by identifying critical residues in a protein’s atomic structure, we can select a critical stability framework within the protein structure essential to proper protein folding. We use...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720693/ https://www.ncbi.nlm.nih.gov/pubmed/29216252 http://dx.doi.org/10.1371/journal.pone.0189064 |