Docking and quantitative structure–activity relationship of bi-cyclic heteroaromatic pyridazinone and pyrazolone derivatives as phosphodiesterase 3A (PDE3A) inhibitors

PDE3s belong to the phosphodiesterases family, where the PDE3A isoform is the major subtype in platelets involved in the cAMP regulation pathway of platelet aggregation. PDE3A inhibitors have been designed as potential antiplatelet agents. In this work, a homology model of PDE3A was developed and us...

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Detalles Bibliográficos
Autores principales: Muñoz-Gutiérrez, Camila, Cáceres-Rojas, Daniela, Adasme-Carreño, Francisco, Palomo, Iván, Fuentes, Eduardo, Caballero, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720733/
https://www.ncbi.nlm.nih.gov/pubmed/29216268
http://dx.doi.org/10.1371/journal.pone.0189213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720733/
https://www.ncbi.nlm.nih.gov/pubmed/29216268
http://dx.doi.org/10.1371/journal.pone.0189213

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