ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodelling by activated myofibroblasts, leads to loss of proper tissue architecture and organ function; however the molecular med...

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Detalles Bibliográficos
Autores principales: Lagares, David, Ghassemi-Kakroodi, Parisa, Tremblay, Caroline, Santos, Alba, Probst, Clemens K., Franklin, Alicia, Santos, Daniela M., Grasberger, Paula, Ahluwalia, Neil, Montesi, Sydney B., Shea, Barry S., Black, Katharine E., Knipe, Rachel, Blati, Meryem, Baron, Murray, Wu, Brian, Fahmi, Hassan, Gandhi, Rajiv, Pardo, Annie, Selman, Moisés, Wu, Jiangping, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Tager, Andrew M., Kapoor, Mohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720906/
https://www.ncbi.nlm.nih.gov/pubmed/29058717
http://dx.doi.org/10.1038/nm.4419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720906/
https://www.ncbi.nlm.nih.gov/pubmed/29058717
http://dx.doi.org/10.1038/nm.4419

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