Cargando…

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

Epithelial–mesenchymal transition (EMT) plays key roles during embryonic development, wound healing and cancer metastasis. Cells in a partial EMT or hybrid epithelial/mesenchymal (E/M) phenotype exhibit collective cell migration, forming clusters of circulating tumour cells—the primary drivers of me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bocci, Federico, Jolly, Mohit K., Tripathi, Satyendra C., Aguilar, Mitzi, Hanash, Samir M., Levine, Herbert, Onuchic, José N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2017
Materias:	Life Sciences–Physics interface
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721160/ https://www.ncbi.nlm.nih.gov/pubmed/29187638 http://dx.doi.org/10.1098/rsif.2017.0512

Ejemplares similares

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype
por: Boareto, Marcelo, et al.
Publicado: (2016)

NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype
por: Bocci, Federico, et al.
Publicado: (2019)

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
por: Jolly, Mohit Kumar, et al.
Publicado: (2017)

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling
por: Bocci, Federico, et al.
Publicado: (2018)

Nrf2 Modulates the Hybrid Epithelial/Mesenchymal Phenotype and Notch Signaling During Collective Cancer Migration
por: Vilchez Mercedes, Samuel A., et al.
Publicado: (2022)

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response
por: Jia, Dongya, et al.
Publicado: (2019)

Stability of the hybrid epithelial/mesenchymal phenotype
por: Jolly, Mohit Kumar, et al.
Publicado: (2016)

Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by random circuit perturbation
por: Huang, Bin, et al.
Publicado: (2020)

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer
por: Jolly, Mohit Kumar, et al.
Publicado: (2018)

NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype
por: Subbalakshmi, Ayalur Raghu, et al.
Publicado: (2020)

Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models
por: Bocci, Federico, et al.
Publicado: (2020)

A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticity
por: Shyam, Sai, et al.
Publicado: (2023)

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
por: Jolly, Mohit Kumar, et al.
Publicado: (2015)

A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells
por: Tripathi, Shubham, et al.
Publicado: (2020)

Comparative Study of Transcriptomics-Based Scoring Metrics for the Epithelial-Hybrid-Mesenchymal Spectrum
por: Chakraborty, Priyanka, et al.
Publicado: (2020)

Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis
por: Qi, Shasha, et al.
Publicado: (2015)

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
por: Zhang, Jianchao, et al.
Publicado: (2016)

Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia
por: Kostiou, Vasiliki, et al.
Publicado: (2021)

Distinguishing mechanisms underlying EMT tristability
por: Jia, Dongya, et al.
Publicado: (2017)

NRF2-dependent Epigenetic Regulation can Promote the Hybrid Epithelial/Mesenchymal Phenotype
por: Jia, Wen, et al.
Publicado: (2022)

Infection, inflammation and intervention: mechanistic modelling of epithelial cells in COVID-19
por: Fadai, Nabil T., et al.
Publicado: (2021)

Collective rotational motion of freely expanding T84 epithelial cell colonies
por: Ascione, Flora, et al.
Publicado: (2023)

Robust cell tracking in epithelial tissues through identification of maximum common subgraphs
por: Kursawe, Jochen, et al.
Publicado: (2016)

Face masking and COVID-19: potential effects of variolation on transmission dynamics
por: Levine, Zachary, et al.
Publicado: (2022)

Editorial: Characterizing the Multi-Faceted Dynamics of Tumor Cell Plasticity
por: Tripathi, Satyendra Chandra, et al.
Publicado: (2021)

NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain
por: Luo, Zhiyuan, et al.
Publicado: (2019)

Decoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in cancer
por: Galbraith, Madeline, et al.
Publicado: (2022)

A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2
por: Deng, Youyuan, et al.
Publicado: (2021)

PriorVAE: encoding spatial priors with variational autoencoders for small-area estimation
por: Semenova, Elizaveta, et al.
Publicado: (2022)

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype
por: Sahoo, Sarthak, et al.
Publicado: (2021)

Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer
por: Li, Jin-Yun, et al.
Publicado: (2019)

High levels of Notch signaling down-regulate Numb and Numblike
por: Chapman, Gavin, et al.
Publicado: (2006)

Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018)

Expression of Notch1 and Numb in small cell lung cancer
por: Kikuchi, Hajime, et al.
Publicado: (2017)

Modelling the direct virus exposure risk associated with respiratory events
por: Wang, Jietuo, et al.
Publicado: (2022)

Inference of COVID-19 epidemiological distributions from Brazilian hospital data
por: Hawryluk, Iwona, et al.
Publicado: (2020)

The collective effect of finite-sized inhomogeneities on the spatial spread of populations in two dimensions
por: Möbius, Wolfram, et al.
Publicado: (2021)

Exact Bayesian inference for the detection of graft-mobile transcripts from sequencing data
por: Tomkins, Melissa, et al.
Publicado: (2022)

OVOL guides the epithelial-hybrid-mesenchymal transition
por: Jia, Dongya, et al.
Publicado: (2015)

Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum
por: Chakraborty, Priyanka, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ea16l4ron72st41n7vko25dqt6