CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3‐Leiden mice

CAT‐2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at the endoplasmic reticulum. In cultured liver cells, CAT‐2003 blocked the maturation of sterol regulatory element‐binding protein (SREBP)‐1 an...

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Detalles Bibliográficos
Autores principales: Zimmer, Michael, Bista, Pradeep, Benson, Ericka L., Lee, Diana Y., Liu, Feng, Picarella, Dominic, Vega, Rick B., Vu, Chi B., Yeager, Maisy, Ding, Min, Liang, Guosheng, Horton, Jay D., Kleemann, Robert, Kooistra, Teake, Morrison, Martine C., Wielinga, Peter Y., Milne, Jill C., Jirousek, Michael R., Nichols, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721391/
https://www.ncbi.nlm.nih.gov/pubmed/29404461
http://dx.doi.org/10.1002/hep4.1042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721391/
https://www.ncbi.nlm.nih.gov/pubmed/29404461
http://dx.doi.org/10.1002/hep4.1042

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