Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer

Background: Germline mutations in the PALB2 gene are associated with the genetic disorder Fanconi anaemia and increased predisposition to cancer. Disease-associated variants are mainly protein-truncating mutations, whereas a few missense substitutions are reported to perturb its interaction with bre...

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Detalles Bibliográficos
Autores principales: Bleuyard, Jean-Yves, Butler, Rosie M., Esashi, Fumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721578/
https://www.ncbi.nlm.nih.gov/pubmed/29387807
http://dx.doi.org/10.12688/wellcomeopenres.13113.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721578/
https://www.ncbi.nlm.nih.gov/pubmed/29387807
http://dx.doi.org/10.12688/wellcomeopenres.13113.2

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