Cargando…

The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study

BACKGROUND: Risk factors for pancreatic cancer include a cluster of metabolic conditions such as obesity, hypertension, dyslipidemia, insulin resistance, and type 2 diabetes. Given that these risk factors are correlated, separating out causal from confounded effects is challenging. Mendelian randomi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carreras-Torres, Robert, Johansson, Mattias, Gaborieau, Valerie, Haycock, Philip C., Wade, Kaitlin H., Relton, Caroline L., Martin, Richard M., Davey Smith, George, Brennan, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721813/ https://www.ncbi.nlm.nih.gov/pubmed/28954281 http://dx.doi.org/10.1093/jnci/djx012

Ejemplares similares

Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank
por: Carreras-Torres, Robert, et al.
Publicado: (2018)

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies(1)
por: Haycock, Philip C, et al.
Publicado: (2016)

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease
por: Richardson, Tom G, et al.
Publicado: (2018)

Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study
por: Carreras-Torres, Robert, et al.
Publicado: (2017)

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis
por: Yarmolinsky, James, et al.
Publicado: (2018)

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
por: Bowden, Jack, et al.
Publicado: (2016)

Recent Developments in Mendelian Randomization Studies
por: Zheng, Jie, et al.
Publicado: (2017)

Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors
por: Howell, Amy Elizabeth, et al.
Publicado: (2018)

The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study
por: Carreras-Torres, Robert, et al.
Publicado: (2016)

BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization
por: Wade, Kaitlin H., et al.
Publicado: (2018)

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study
por: Taylor, Amy E, et al.
Publicado: (2019)

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
por: Taylor, Kurt, et al.
Publicado: (2019)

Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation
por: Leyden, Genevieve M., et al.
Publicado: (2022)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
por: Cho, Yoonsu, et al.
Publicado: (2020)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Richardson, Tom G., et al.
Publicado: (2020)

Assessing the causal role of adiposity on disordered eating in childhood, adolescence, and adulthood: a Mendelian randomization analysis
por: Reed, Zoe E, et al.
Publicado: (2017)

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data
por: Howey, Richard, et al.
Publicado: (2020)

Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study
por: Cho, Yoonsu, et al.
Publicado: (2015)

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
por: Morales Berstein, Fernanda, et al.
Publicado: (2022)

Obesity and Multiple Sclerosis: A Mendelian Randomization Study
por: Mokry, Lauren E., et al.
Publicado: (2016)

Corrigendum: Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study
por: Cho, Yoonsu, et al.
Publicado: (2016)

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk
por: Richardson, Tom G., et al.
Publicado: (2017)

Distilling causality between physical activity traits and obesity via Mendelian randomization
por: Wang, Zhe, et al.
Publicado: (2023)

Guidelines for performing Mendelian randomization investigations: update for summer 2023
por: Burgess, Stephen, et al.
Publicado: (2023)

The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study
por: Johansson, Mattias, et al.
Publicado: (2019)

Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer
por: Bull, Caroline J, et al.
Publicado: (2016)

Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans
por: Cho, Yoonsu, et al.
Publicado: (2018)

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
por: Borges, Maria Carolina, et al.
Publicado: (2022)

Design and quality control of large-scale two-sample Mendelian randomization studies
por: Haycock, Philip C, et al.
Publicado: (2023)

Causal relationships between lipid and glycemic levels in an Indian population: A bidirectional Mendelian randomization approach
por: Agarwal, Tripti, et al.
Publicado: (2020)

Mendelian randomization: genetic anchors for causal inference in epidemiological studies
por: Davey Smith, George, et al.
Publicado: (2014)

Bias in Mendelian randomization due to assortative mating
por: Hartwig, Fernando Pires, et al.
Publicado: (2018)

Evaluating the potential role of pleiotropy in Mendelian randomization studies
por: Hemani, Gibran, et al.
Publicado: (2018)

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study
por: Bell, Joshua A., et al.
Publicado: (2018)

Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization
por: Gormley, Mark, et al.
Publicado: (2023)

Mendelian randomization applied to pharmaceutical use: the case of metformin and lung cancer
por: Yarmolinsky, James, et al.
Publicado: (2020)

Exploring a causal role of DNA methylation in the relationship between maternal vitamin B(12) during pregnancy and child’s IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study
por: Caramaschi, Doretta, et al.
Publicado: (2017)

Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study
por: Howell, A. E., et al.
Publicado: (2020)

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study
por: Smith, Madeleine L., et al.
Publicado: (2023)

Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways
por: Jamieson, Emily, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5ncbvdklfoiifik72j0l9gn112