Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β

Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrP(C)) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A(2) (cPLA(2)) to lipid rafts and activation of cPLA(2). Th...

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Detalles Bibliográficos
Autor principal: Bate, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Invited Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721958/
https://www.ncbi.nlm.nih.gov/pubmed/29238218
http://dx.doi.org/10.1177/1179069517733096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721958/
https://www.ncbi.nlm.nih.gov/pubmed/29238218
http://dx.doi.org/10.1177/1179069517733096

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