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Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrP(C)) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A(2) (cPLA(2)) to lipid rafts and activation of cPLA(2). Th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721958/ https://www.ncbi.nlm.nih.gov/pubmed/29238218 http://dx.doi.org/10.1177/1179069517733096 |