AMP-activated protein kinase: a target for drugs both ancient and modern

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. It is activated, by a mechanism requiring the tumor suppressor LKB1, by metabolic stresses that increase cellular ADP:ATP and/or AMP:ATP ratios. Once activated, it switches on catabolic pathways that generate ATP, while s...

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Detalles Bibliográficos
Autores principales: Hardie, D. Grahame, Ross, Fiona A., Hawley, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722193/
https://www.ncbi.nlm.nih.gov/pubmed/23102217
http://dx.doi.org/10.1016/j.chembiol.2012.08.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722193/
https://www.ncbi.nlm.nih.gov/pubmed/23102217
http://dx.doi.org/10.1016/j.chembiol.2012.08.019

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