Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and malignant pediatric brain tumor. Polo-like kinase 1 (PLK1) is highly expressed in many cancers and essential for mitosis. Overexpression of PLK1 promotes chromosome instability and aneuploidy by overriding the G2-M DNA damage and spindle c...

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Detalles Bibliográficos
Autores principales: Alimova, Irina, Pierce, Angela M., Harris, Peter, Donson, Andrew, Birks, Diane K., Prince, Eric, Balakrishnan, Ilango, Foreman, Nicholas K., Kool, Marcel, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722562/
https://www.ncbi.nlm.nih.gov/pubmed/29228610
http://dx.doi.org/10.18632/oncotarget.21932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722562/
https://www.ncbi.nlm.nih.gov/pubmed/29228610
http://dx.doi.org/10.18632/oncotarget.21932

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