Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

Constitutive JAK/STAT3 signaling contributes to disease progression in many lymphoproliferative disorders. Recent genetic analyses have revealed gain-of-function STAT3 mutations in lymphoid cancers leading to hyperactivation of STAT3, which may represent a potential therapeutic target. Using a funct...

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Detalles Bibliográficos
Autores principales: Kuusanmäki, Heikki, Dufva, Olli, Parri, Elina, van Adrichem, Arjan J., Rajala, Hanna, Majumder, Muntasir M., Yadav, Bhagwan, Parsons, Alun, Chan, Wing C., Wennerberg, Krister, Mustjoki, Satu, Heckman, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722580/
https://www.ncbi.nlm.nih.gov/pubmed/29228628
http://dx.doi.org/10.18632/oncotarget.22178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722580/
https://www.ncbi.nlm.nih.gov/pubmed/29228628
http://dx.doi.org/10.18632/oncotarget.22178

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