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Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer

The membrane-bound molecules programmed death 1 (PD-1) and its ligand PD-L1 (PD-1/PD-L1) belong to the immune checkpoint pathway. PD-1 pathway downregulates effector T cells in immune response, thereby causing immune suppression. Recent studies have revealed that membrane-bound PD-1 and PD-L1 also h...

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Detalles Bibliográficos
Autores principales: Zhu, Xinxin, Lang, Jinghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722594/
https://www.ncbi.nlm.nih.gov/pubmed/29228642
http://dx.doi.org/10.18632/oncotarget.18311