Generation of TCRs of higher affinity by antigen-driven differentiation of progenitor T cells in vitro

Many promising targets for T cell-based cancer immunotherapies are self-antigens. During thymic selection, T cells bearing TCRs with high affinity for self-antigen are eliminated. The affinity of the remaining low avidity TCRs can be improved to increase their anti-tumor efficacy, but conventional s...

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Detalles Bibliográficos
Autores principales: Schmitt, Thomas M., Aggen, David H., Ishida-Tsubota, Kumiko, Ochsenreither, Sebastian, Kranz, David M., Greenberg, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722674/
https://www.ncbi.nlm.nih.gov/pubmed/29106410
http://dx.doi.org/10.1038/nbt.4004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722674/
https://www.ncbi.nlm.nih.gov/pubmed/29106410
http://dx.doi.org/10.1038/nbt.4004

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