BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation

Insulin-resistance is the main cause of type 2 diabetes. Here we describe the identification and characterization of BMP2 and BMP6 as new insulin-sensitizing growth factors in mature adipocytes. We show that BMP2 and BMP6 lead to enhanced insulin-mediated glucose uptake in both insulin-sensitive and...

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Detalles Bibliográficos
Autores principales: Schreiber, Isabelle, Dörpholz, Gina, Ott, Claus-Eric, Kragesteen, Bjørt, Schanze, Nancy, Lee, Cory Thomas, Köhrle, Josef, Mundlos, Stefan, Ruschke, Karen, Knaus, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722815/
https://www.ncbi.nlm.nih.gov/pubmed/29222456
http://dx.doi.org/10.1038/s41598-017-17595-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722815/
https://www.ncbi.nlm.nih.gov/pubmed/29222456
http://dx.doi.org/10.1038/s41598-017-17595-5

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