Spatial competition constrains resistance to targeted cancer therapy

Adaptive therapy (AT) aims to control tumour burden by maintaining therapy-sensitive cells to exploit their competition with resistant cells. This relies on the assumption that resistant cells have impaired cellular fitness. Here, using a model of resistance to a pharmacological cyclin-dependent kin...

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Detalles Bibliográficos
Autores principales: Bacevic, Katarina, Noble, Robert, Soffar, Ahmed, Wael Ammar, Orchid, Boszonyik, Benjamin, Prieto, Susana, Vincent, Charles, Hochberg, Michael E., Krasinska, Liliana, Fisher, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722825/
https://www.ncbi.nlm.nih.gov/pubmed/29222471
http://dx.doi.org/10.1038/s41467-017-01516-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722825/
https://www.ncbi.nlm.nih.gov/pubmed/29222471
http://dx.doi.org/10.1038/s41467-017-01516-1

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