Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β

Monoclonal antibodies (mAbs) have not been used as positron emission tomography (PET) ligands for in vivo imaging of the brain because of their limited passage across the blood-brain barrier (BBB). However, due to their high affinity and specificity, mAbs may be an attractive option for brain PET if...

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Detalles Bibliográficos
Autores principales: Sehlin, Dag, Fang, Xiaotian T., Meier, Silvio R., Jansson, Malin, Syvänen, Stina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722892/
https://www.ncbi.nlm.nih.gov/pubmed/29222502
http://dx.doi.org/10.1038/s41598-017-17358-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722892/
https://www.ncbi.nlm.nih.gov/pubmed/29222502
http://dx.doi.org/10.1038/s41598-017-17358-2

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