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Structure and Dynamics of Cas9 HNH Domain Catalytic State
The bacterial CRISPR-Cas9 immune system has been harnessed as a powerful and versatile genome-editing tool and holds immense promise for future therapeutic applications. Despite recent advances in understanding Cas9 structures and its functional mechanism, little is known about the catalytic state o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722908/ https://www.ncbi.nlm.nih.gov/pubmed/29222528 http://dx.doi.org/10.1038/s41598-017-17578-6 |