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Structure and Dynamics of Cas9 HNH Domain Catalytic State

The bacterial CRISPR-Cas9 immune system has been harnessed as a powerful and versatile genome-editing tool and holds immense promise for future therapeutic applications. Despite recent advances in understanding Cas9 structures and its functional mechanism, little is known about the catalytic state o...

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Detalles Bibliográficos
Autores principales:	Zuo, Zhicheng, Liu, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722908/ https://www.ncbi.nlm.nih.gov/pubmed/29222528 http://dx.doi.org/10.1038/s41598-017-17578-6

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