Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

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Detalles Bibliográficos
Autores principales: Baker, Ann-Marie, Huang, Weini, Wang, Xiao-Ming Mindy, Jansen, Marnix, Ma, Xiao-Jun, Kim, Jeffrey, Anderson, Courtney M., Wu, Xingyong, Pan, Liuliu, Su, Nan, Luo, Yuling, Domingo, Enric, Heide, Timon, Sottoriva, Andrea, Lewis, Annabelle, Beggs, Andrew D., Wright, Nicholas A., Rodriguez-Justo, Manuel, Park, Emily, Tomlinson, Ian, Graham, Trevor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722928/
https://www.ncbi.nlm.nih.gov/pubmed/29222441
http://dx.doi.org/10.1038/s41467-017-02295-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722928/
https://www.ncbi.nlm.nih.gov/pubmed/29222441
http://dx.doi.org/10.1038/s41467-017-02295-5

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