Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, Ann-Marie, Huang, Weini, Wang, Xiao-Ming Mindy, Jansen, Marnix, Ma, Xiao-Jun, Kim, Jeffrey, Anderson, Courtney M., Wu, Xingyong, Pan, Liuliu, Su, Nan, Luo, Yuling, Domingo, Enric, Heide, Timon, Sottoriva, Andrea, Lewis, Annabelle, Beggs, Andrew D., Wright, Nicholas A., Rodriguez-Justo, Manuel, Park, Emily, Tomlinson, Ian, Graham, Trevor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722928/
https://www.ncbi.nlm.nih.gov/pubmed/29222441
http://dx.doi.org/10.1038/s41467-017-02295-5

Ejemplares similares

Ejemplares similares