Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood. Here, we demonstrate that HFD increases palmitic acid deposition in the hippocampus and induces hippocampal insulin resi...

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Detalles Bibliográficos
Autores principales: Spinelli, Matteo, Fusco, Salvatore, Mainardi, Marco, Scala, Federico, Natale, Francesca, Lapenta, Rosita, Mattera, Andrea, Rinaudo, Marco, Li Puma, Domenica Donatella, Ripoli, Cristian, Grassi, Alfonso, D’Ascenzo, Marcello, Grassi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722929/
https://www.ncbi.nlm.nih.gov/pubmed/29222408
http://dx.doi.org/10.1038/s41467-017-02221-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722929/
https://www.ncbi.nlm.nih.gov/pubmed/29222408
http://dx.doi.org/10.1038/s41467-017-02221-9

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