Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

The structural transitions required for insulin to activate its receptor and initiate regulation of glucose homeostasis are only partly understood. Here, using ring-closing metathesis, we substitute the A6-A11 disulfide bond of insulin with a rigid, non-reducible dicarba linkage, yielding two distin...

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Detalles Bibliográficos
Autores principales: van Lierop, Bianca, Ong, Shee Chee, Belgi, Alessia, Delaine, Carlie, Andrikopoulos, Sofianos, Haworth, Naomi L., Menting, John G., Lawrence, Michael C., Robinson, Andrea J., Forbes, Briony E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722942/
https://www.ncbi.nlm.nih.gov/pubmed/29222417
http://dx.doi.org/10.1038/s41598-017-16876-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722942/
https://www.ncbi.nlm.nih.gov/pubmed/29222417
http://dx.doi.org/10.1038/s41598-017-16876-3

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