Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways

Hypoxia-inducible factor 1α (HIF1α) induces the expression of several hundred genes in hypoxia aiming at restoration of oxygen homeostasis. HIF prolyl-4-hydroxylases (HIF-P4Hs) regulate the stability of HIF1α in an oxygen-dependent manner. Hypoxia is a common feature in inflammation and cancer and t...

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Detalles Bibliográficos
Autores principales: Ullah, Karim, Rosendahl, Ann-Helen, Izzi, Valerio, Bergmann, Ulrich, Pihlajaniemi, Taina, Mäki, Joni M., Myllyharju, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722952/
https://www.ncbi.nlm.nih.gov/pubmed/29222481
http://dx.doi.org/10.1038/s41598-017-17376-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722952/
https://www.ncbi.nlm.nih.gov/pubmed/29222481
http://dx.doi.org/10.1038/s41598-017-17376-0

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