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COMT Val(158)Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function

Evidence suggests that dopamine levels in the prefrontal cortex (PFC) modulate executive functions. A key regulator of PFC dopamine is catechol-O-methyltransferase (COMT). The activity level of the COMT enzyme are influenced by sex and the Val(158)Met polymorphism (rs4680) of the COMT gene, with mal...

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Detalles Bibliográficos
Autores principales:	Elton, Amanda, Smith, Christopher T., Parrish, Michael H., Boettiger, Charlotte A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723646/ https://www.ncbi.nlm.nih.gov/pubmed/29270116 http://dx.doi.org/10.3389/fnhum.2017.00578

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