Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation

Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel transient receptor potential ankyrin 1 (TRPA1). However, rigorous...

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Detalles Bibliográficos
Autores principales: Griggs, Ryan B., Laird, Don E., Donahue, Renee R., Fu, Weisi, Taylor, Bradley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723675/
https://www.ncbi.nlm.nih.gov/pubmed/29270106
http://dx.doi.org/10.3389/fnins.2017.00679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723675/
https://www.ncbi.nlm.nih.gov/pubmed/29270106
http://dx.doi.org/10.3389/fnins.2017.00679

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