Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway

The Ras-Raf-MEK-ERK pathway plays a central role in tumorigenesis and is a target for anticancer therapy. The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in Ras pathway. However, activation of cytoprotective...

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Detalles Bibliográficos
Autores principales: Kochetkova, Elena Y., Blinova, Galina I., Bystrova, Olga A., Martynova, Marina G., Pospelov, Valery A., Pospelova, Tatiana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723691/
https://www.ncbi.nlm.nih.gov/pubmed/29140794
http://dx.doi.org/10.18632/aging.101325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723691/
https://www.ncbi.nlm.nih.gov/pubmed/29140794
http://dx.doi.org/10.18632/aging.101325

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