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Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway

The Ras-Raf-MEK-ERK pathway plays a central role in tumorigenesis and is a target for anticancer therapy. The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in Ras pathway. However, activation of cytoprotective...

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Detalles Bibliográficos
Autores principales:	Kochetkova, Elena Y., Blinova, Galina I., Bystrova, Olga A., Martynova, Marina G., Pospelov, Valery A., Pospelova, Tatiana V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723691/ https://www.ncbi.nlm.nih.gov/pubmed/29140794 http://dx.doi.org/10.18632/aging.101325

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