TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Cellular senescence is a cell fate program that entails essentially irreversible proliferative arrest in response to damage signals. Tumor necrosis factor-alpha (TNFα), an important pro-inflammatory cytokine secreted by some types of senescent cells, can induce senescence in mouse and human cells. H...

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Detalles Bibliográficos
Autores principales: Kandhaya-Pillai, Renuka, Miro-Mur, Francesc, Alijotas-Reig, Jaume, Tchkonia, Tamara, Kirkland, James L., Schwartz, Simo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723694/
https://www.ncbi.nlm.nih.gov/pubmed/29176033
http://dx.doi.org/10.18632/aging.101328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723694/
https://www.ncbi.nlm.nih.gov/pubmed/29176033
http://dx.doi.org/10.18632/aging.101328

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