Distortion of K(B) estimates of endothelin‐1 ET(A) and ET(B) receptor antagonists in pulmonary arteries: Possible role of an endothelin‐1 clearance mechanism

Dual endothelin ET(A) and ET(B) receptor antagonists are approved therapy for pulmonary artery hypertension (PAH). We hypothesized that ET(B) receptor‐mediated clearance of endothelin‐1 at specific vascular sites may compromise this targeted therapy. Concentration‐response curves (CRC) to endothelin...

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Detalles Bibliográficos
Autores principales: Angus, James A., Hughes, Richard J. A., Wright, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723704/
https://www.ncbi.nlm.nih.gov/pubmed/29226623
http://dx.doi.org/10.1002/prp2.374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723704/
https://www.ncbi.nlm.nih.gov/pubmed/29226623
http://dx.doi.org/10.1002/prp2.374

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