Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models

[Image: see text] Soybean lipoxygenase (SLO) is a prototype for nonadiabatic hydrogen tunneling reactions and, as such, has served as the subject of numerous theoretical studies. In this work, we report a nearly temperature-independent kinetic isotope effect (KIE) with an average KIE value of 661 ±...

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Detalles Bibliográficos
Autores principales: Hu, Shenshen, Soudackov, Alexander V., Hammes-Schiffer, Sharon, Klinman, Judith P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724529/
https://www.ncbi.nlm.nih.gov/pubmed/29250456
http://dx.doi.org/10.1021/acscatal.7b00688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724529/
https://www.ncbi.nlm.nih.gov/pubmed/29250456
http://dx.doi.org/10.1021/acscatal.7b00688

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