Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors

Medulloblastoma is the most common malignant brain cancer of childhood. Further understanding of tumorigenic mechanisms may define new therapeutic targets. Geminin maintains genome fidelity by controlling re-initiation of DNA replication within a cell cycle. In some contexts, Geminin inhibition indu...

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Detalles Bibliográficos
Autores principales: Sankar, Savita, Patterson, Ethan, Lewis, Emily M., Waller, Laura E., Tong, Caili, Dearborn, Joshua, Wozniak, David, Rubin, Joshua B., Kroll, Kristen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724806/
https://www.ncbi.nlm.nih.gov/pubmed/29234490
http://dx.doi.org/10.18632/genesandcancer.157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724806/
https://www.ncbi.nlm.nih.gov/pubmed/29234490
http://dx.doi.org/10.18632/genesandcancer.157

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