Pockets as structural descriptors of EGFR kinase conformations

Epidermal Growth Factor Receptor (EGFR), a tyrosine kinase receptor, is one of the main tumor markers in different types of cancers. The kinase native state is mainly composed of two populations of conformers: active and inactive. Several sequence variations in EGFR kinase region promote the differe...

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Detalles Bibliográficos
Autores principales: Hasenahuer, Marcia Anahi, Barletta, German Patricio, Fernandez-Alberti, Sebastián, Parisi, Gustavo, Fornasari, María Silvina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724837/
https://www.ncbi.nlm.nih.gov/pubmed/29228029
http://dx.doi.org/10.1371/journal.pone.0189147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724837/
https://www.ncbi.nlm.nih.gov/pubmed/29228029
http://dx.doi.org/10.1371/journal.pone.0189147

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