Developing Neolignans as Proangiogenic Agents: Stereoselective Total Syntheses and Preliminary Biological Evaluations of the Four Guaiacylglycerol 8-O-4′-Coniferyl Ethers

[Image: see text] Stereoselective total syntheses of the four stereoisomeric forms of guaiacylglycerol 8-O-4′-coniferyl ether, viz., compounds 1, ent-1, 2, and ent-2, have been established. The key step involves an Evans/Seebach auxiliary-controlled and syn-selective aldol process followed, in the r...

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Detalles Bibliográficos
Autores principales: Buckler, Joshua N., Banwell, Martin G., Kordbacheh, Farzaneh, Parish, Christopher R., Santiago, Fernando S., Khachigian, Levon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724931/
https://www.ncbi.nlm.nih.gov/pubmed/29242850
http://dx.doi.org/10.1021/acsomega.7b01459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724931/
https://www.ncbi.nlm.nih.gov/pubmed/29242850
http://dx.doi.org/10.1021/acsomega.7b01459

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